New: Symeres and Yoneda Labs Use AI to Optimize Cross-Coupling Reactions Read more

Services

Put Our Lab to Work

Bring us your hardest chemistry.
Our HTE lab will give you the answers.

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01

Reaction Troubleshooting

Medicinal chemistry

Tried every ligand in the drawer and the carbons still won't couple? We'll make it work: our HTE lab screens hundreds of conditions to find the ones that deliver your product, with an impurity profile that won't fight you on the column.

02

Reaction Optimization

Process chemistry

The med chem route works, but only with a silver salt your plant will never let through the door? Yield stuck at "fine" while the impurity table keeps growing? We maximize your yield on process-friendly reagents and give you an impurity profile you control.

03

Route Scouting

Medicinal & Process chemistry

Retrosynthesis left you with five plausible disconnections and no idea which one survives contact with real material? We run the candidate routes head to head in our lab and tell you which one actually delivers, before you spend months marching down the wrong one.

04

Library Enablement

Medicinal chemistry

Conditions worked on the model substrate until the first real analog brought a basic nitrogen and killed the party? We screen a representative scope of your substrates and hand you a few general conditions, or a simple decision algorithm, that cover the whole library.

05

Library Synthesis

Medicinal chemistry

A few hundred analogs on the whiteboard and nowhere near enough hands to run the columns? Leave the labor to our robots. We synthesize your library in our lab and deliver it purified, in whatever standard format you need.

Our Technology

State-of-the-art instrumentation, custom software, and frontier AI models.

Liquid dispensing automation filling 96-well plates

The Lab

Glovebox — air- and moisture-sensitive chemistry under inert atmosphere.

Dispensing automation — state-of-the-art solid and liquid dispensing.

LC-MS instrument and deconvolved chromatograms

The Analytics

LC-MS, NMR & prep-HPLC — analysis and purification in-house.

AI-assisted analysis — custom software and AI models for assisted LC-MS and NMR analysis.

3D structures of palladium ligand complexes

The Intelligence

Reactivity models — trained on tens of thousands of proprietary data points.

Bayesian Optimization — the best conditions in as few experiments as possible.

Ready to Put Our Lab to Work?

Tell us about your reaction, library, or route. We'll take it from here.